ORAL CHALLENGE WITH SHIGELLA FLEXNERI 2a IN CYNOMOLGUS MONKEYS HAVING EXTREMELY HIGH TITER OF SERUM AGGLUTININ
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چکیده
منابع مشابه
Bacillary dysentery in cynomolgus monkeys following the administration with Shigella flexneri 2A by the anal route.
A series of studies on experimental shigellosis in monkeys has been made by an oral administration method (Honjo et al., 1964; Ogawa et al., 1964, 1966; Takasaka et al., 1967; Honjo et al., 1967, 1968, 1969; Takasaka et al., 1969, 1970). This method, however, is more or less disadvantageous for quantitative analyses, since it is uncertain whether all the orally administered bacilli can reach th...
متن کاملVaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602.
The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin) (S. Barzu, A. Fontaine, P. J. Sansonetti, and A. Phalipon, Infect. Immun. 64:1190-1196, 1996). Dose selection studies showed that SC602 causes shigellosis in a majority of volunteers when 3 x 1...
متن کاملDipstick for Rapid Diagnosis of Shigella flexneri 2a in Stool
BACKGROUND Shigellosis or bacillary dysentery, an acute bloody diarrhoea, is a major public health burden in developing countries. In the absence of prompt and appropriate treatment, the infection is often fatal, particularly in young malnourished children. Here, we describe a new diagnostic test for rapid detection, in stool, at the bedside of patients, of Shigella flexneri 2a, the most predom...
متن کاملIpaD-loaded N-trimethyl Chitosan Nanoparticles Can Efficiently Protect Guinea Pigs against Shigella Flexneri
Background: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). Objective: To evaluate the efficiency of O-metylated free trimethyl chitosan na...
متن کاملBiological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.
A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1968
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.21.283